Sclerosing mesenteritis disease – symptoms, causes, diagnosis & stem cell therapy

Sclerosing mesenteritis is a rare illness. It causes chronic inflammation and scarring of the mesentery. People with this disease often feel abdominal pain, have diarrhea, or face bowel blockages. The exact cause is still a mystery, and treating it is challenging.

Doctors might suggest using steroids, colchicine, or tamoxifen. They could also recommend some special drugs to help your immune system. But if these don’t work, surgery might be needed to fix a bowel blockage.

Key Takeaways:

• Sclerosing mesenteritis is a rare disease involving inflammation and fibrosis of the mesentery.
• Symptoms include abdominal pain, diarrhea, and bowel obstruction.
• The cause of sclerosing mesenteritis remains unknown.
• Treatment options include steroids, colchicine, tamoxifen, and immunomodulatory agents.
• In severe cases, surgical intervention may be required to relieve bowel obstruction.

Causes and Diagnosis of Sclerosing Mesenteritis

Sclerosing mesenteritis (SM) is a rare disease that affects the tissue connecting the intestines to the abdomen wall. Its exact cause is still unknown. But, we do know that several things may lead to it.

Autoimmune Disease of the Mesentery: Doctors think SM may be an autoimmune disease. In autoimmune diseases, the immune system attacks the body’s own cells. This can cause swelling and scarring in the mesentery, leading to SM symptoms.

Possible Triggers: We’re still not sure what exactly triggers SM. But, we know some factors that might contribute to it. These include:

• Trauma: Sometimes, injuries to the abdomen or surgeries can happen before SM shows up.
• Infection: Evidence shows that certain infections, especially viral or bacterial ones, might start SM through an immune response.
• Certain Cancers: Some cancers, like lymphoma and melanoma, might be linked to SM. The body’s immune response to these cancers could contribute to SM development.

Diagnosing Sclerosing Mesenteritis:

Diagnosing SM is tough because it’s rare and its symptoms look like other conditions. Doctors use a mix of checking symptoms, imaging tests, and biopsies to diagnose it precisely.

Imaging Studies: CT scans are key in diagnosing SM. They let doctors see the mesentery clearly. This helps spot abnormalities like mass structures and fibrosis related to SM.

Biopsy: Sometimes, a biopsy is necessary to fully confirm SM. During a biopsy, a small tissue sample is taken from the mesentery to check for signs of SM under a microscope.

Treatment Options for Sclerosing Mesenteritis

Treating sclerosing mesenteritis, or mesenteric nodular panniculitis, is hard. There are few treatment choices and no set plan. Doctors use different methods depending on each patient’s needs.

Doctors often use steroids to reduce swelling in sclerosing mesenteritis. They work well for some, but other drugs are also helpful. Medicines like colchicine, tamoxifen, and certain immunomodulatory drugs can be effective. But, their results can differ for each person.

If medicines don’t work, surgery might be needed. This is done for those with serious symptoms or if the bowels are blocked. The best treatment is based on the patient’s symptoms and how they respond to drugs.

Treating sclerosing mesenteritis is personalized. Doctors aim to improve the patient’s health and lessen symptoms, even with limited treatments available.