Delayed sleep phase syndrome disease – symptoms, causes, diagnosis & stem cell therapy

Delayed sleep phase syndrome (DSPS) is a type of circadian rhythm sleep disorder. It affects the timing of when you sleep and wake up. People with DSPS find it hard to fall asleep at night when most people do. This is because their sleep starts at least two hours later. It can cause trouble getting up at a normal morning time.

About 15% of teenagers and adults are affected by DSPS. It’s more than just being a night owl. It’s not a choice to stay up late. It’s because the body’s clock runs late. Signs of DSPS include problems falling asleep, trouble waking up on time, feeling very tired during the day, and not having other sleep problems like sleep apnea. DSPS can also be linked to mental and behavioral issues, and it might run in families.

Finding out if someone has DSPS can be hard. This is because it looks like other things, like feeling down or not sleeping well. Doctors who specialize in sleep can help. They might ask about your health history, have you keep a sleep diary, use a device that tracks your movements (actigraphy), or do a sleep study (polysomnogram). These tests can show if your sleep patterns are due to DSPS.

Treating DSPS often means trying several approaches. These can include changing your sleep schedule, using bright light, taking melatonin, and making your sleep area better. DSPS is mostly seen in young people, but it can happen at any age. If you’re having sleep problems for more than a week, it’s a good idea to see a doctor.

Key Takeaways:

• Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder that causes a delay in the sleep-wake cycle.
• Signs of DSPS include difficulty falling asleep, difficulty waking up at a normal time, excessive daytime sleepiness, and a lack of other sleep issues.
• A sleep specialist can conduct tests to diagnose DSPS, such as gathering medical history, requesting a sleep log, performing actigraphy, and conducting a polysomnogram.
• Treatment for DSPS often involves adjusting the internal clock, using bright light therapy, taking melatonin supplements, and improving sleep hygiene.
• If sleep issues persist for at least seven days, it is important to seek medical attention.

Causes and Genetics of Delayed Sleep Phase Syndrome

The exact cause of delayed sleep phase syndrome (DSPS) is not clear. It’s thought to come from both genetic traits and changes we go through in puberty. If someone in your family has this disorder, you might get it too.

Researchers have found certain genes related to DSPS, like PER2 and CKIε. Changes in these genes can mess up our body’s natural clock. This can cause our sleep pattern to get off track.

PER2: PER2 helps control the day-night cycle and produces the PER2 protein. When PER2 doesn’t work right due to a mutation, it can throw off our sleep schedule.

CKIε: CKIε makes an enzyme that helps set our internal clock. If there’s a mutation in CKIε, our daily rhythm could get shorter. This is one reason why people with DSPS often sleep later than usual.

Other genes like hCRY2 and PER3 are also linked to sleep disorders. They’re often tied to Advanced Sleep Phase Disorder, which is like the opposite of DSPS. This shows how complex these sleep issues can be.

DSPS isn’t something you choose. It’s a real health issue that affects your body’s clock. Because of this, it’s hard for people with DSPS to sleep and wake up at normal times.

Genetics and Circadian Clock

Our body’s clock and our genes are tightly connected. If something is off in our circadian rhythm, it can cause sleep problems like DSPS.

Looking at the genetics of DSPS can teach us a lot. It might help us find better ways to treat the disorder. Understanding these genes can lead to personalized therapies for those with DSPS.

We’re still learning about the genetic side of DSPS. But, this research offers hope for better, custom treatments. These treatments could focus on each person’s unique genetic makeup and issues.

Diagnosis and Treatment of Delayed Sleep Phase Syndrome

Diagnosing delayed sleep phase syndrome (DSPS) is tricky. Its symptoms look like those of depression or insomnia. If you’ve had trouble sleeping for a week, see a sleep doctor.

A sleep specialist can use different techniques to diagnose DSPS. They might:

1. Gathering medical history: The specialist will ask about your health, looking for anything affecting your sleep.
2. Requesting a sleep log: Write down your sleep times and any issues you have during the night. This record can help the doctor figure things out.
3. Performing actigraphy: You might wear a device that keeps track of your movements and light exposure. This info helps study your sleep and body clock.
4. Conducting a polysomnogram: This detailed test records your body’s sleep signals. It helps make sure DSPS is the right diagnosis.

After a DSPS diagnosis, treatment focuses on fixing the sleep schedule. Common treatments include:

1. Adjusting the sleep schedule: You can move bedtime earlier each night. You can also delay bedtime every six days to regulate your body clock.
2. Bright light therapy: Sitting near a bright light box for 30 minutes in the morning helps reset your internal clock.
3. Melatonin supplements: Doctor-prescribed melatonin can help. They’ll tell you the right dose and when to take it.
4. Improving sleep hygiene: Having a set sleep time, avoiding screens at night, and cutting down on caffeine and alcohol can make a big difference.

DSPS tends to stay into adulthood. Managing it with treatment is key to living well and sleeping better.

Conclusion

Delaying sleep may mean more than just liking nights. It could be a sign of a sleep disorder called Delayed Sleep Phase Syndrome (DSPS). This issue delays when we feel sleepy at night. It’s more common among teenagers. They might find it hard to fall asleep at a good time.

Figuring out if someone has DSPS is tough. Doctors use things like asking about your health, keeping a sleep diary, using a special watch to monitor sleep (actigraphy), and sleep studies (polysomnograms). These tests can show if your sleep schedule is off.

If you have DSPS, treatment can help. It focuses on getting your sleep routine back on track. This might involve changing your bedtime bit by bit, using bright lights to adjust your body clock, taking melatonin, and improving how you sleep.

While DSPS can’t be cured, managing your sleep and sticking to treatment can make things better. If you still find it hard to sleep, seeing a sleep expert is important. They can create a custom plan to help you. Dealing with DSPS means you can sleep better and feel more in charge of your life.