Asthma is a long-term lung issue that affects people all over the world. It causes the airways to be inflamed, resulting in problems like coughing, making a wheezing sound, and finding it hard to breathe. This condition hits about 10% of the global population, with kids being the most affected.
The exact reasons for asthma are still a mystery. However, we know that your genes and the things around you both have a part. Things like pollen, pet dander, lung infections, and even air with cigarette smoke or pollution can make asthma worse.
Diagnosing asthma involves a few tests. Doctors use tests like spirometry and measuring exhaled nitric oxide to see how bad the asthma is. These tests are key in figuring out the best treatment plan.
Unfortunately, there is no cure for asthma. But, people can keep it under control. By using inhalers and taking certain medications, the inflammation can be reduced. Making changes to your lifestyle and avoiding the things that set off your asthma also help keep it at bay.
Stem cell therapy holds a lot of hope for asthma treatment. Scientists believe that stem cells can help the immune system work better. They might also aid in fixing lung damage and cutting down on airway inflammation.
Key Takeaways:
- Asthma is a chronic respiratory disease characterized by inflammation in the airways, leading to symptoms such as coughing, wheezing, and shortness of breath.
- Environmental factors and genetic predisposition play a role in the development of asthma.
- Diagnosis of asthma involves various tests to determine its presence and severity.
- Asthma can be managed through medications, lifestyle modifications, and self-management techniques.
- Stem cell therapy shows promise in improving immune function, promoting lung tissue regeneration, and reducing inflammation in the airways.
What is Asthma?
Asthma is a long-term lung condition. It causes the airways to become inflamed and narrow. This makes it hard to breathe. People with asthma often have coughing, wheezing, and feel like they can’t take a deep breath.
It’s a condition you have for a long time. Millions around the world, especially children, have it. It can be set off by allergens, infections, and pollution. This makes the airways swell, making it tough to breathe.
To put it simply, asthma means having trouble breathing from time to time. It’s because the airways get smaller, making it harder for air to move in and out.
Asthma Causes
We’re still not sure about all the causes of asthma. But both genes and the environment seem to play a role. Having family members with asthma can increase the odds of you having it. Also, things like infections, allergens, smoke, and pollution can start asthma symptoms.
Asthma Diagnosis
Doctors use a few things to diagnose asthma. They look at your history, check your breathing, and might do some tests. These tests can include checking how well your lungs work or measuring inflammation in your airways. They might also test to see what things might trigger your asthma.
Asthma Treatment
There are many ways to treat asthma. The goal is to keep symptoms under control and the airways open. Doctors often use inhalers to send medicine straight to the lungs. It can include breathing exercises or watching out for things that make asthma worse.
| Treatment Options for Asthma | Advantages | Disadvantages |
|---|---|---|
| Medications (bronchodilators, inhaled corticosteroids) | – Control symptoms – Reduce inflammation |
– Potential side effects – Long-term use |
| Lifestyle Modifications | – Avoid triggers – Maintain a healthy weight |
– Requires lifestyle changes – Some triggers may be unavoidable |
| Self-Management Techniques | – Recognize and respond to symptoms – Proper inhaler technique |
– Requires active participation – Learning curve for inhaler use |
Researchers are also looking into using stem cells to treat asthma. The early findings are promising. They suggest that mesenchymal stem cells can help the immune system, heal lung tissue, and lower inflammation. But more studies are needed to know for certain if this is a good treatment option.
Symptoms of Asthma
Asthma shows as wheezing, chest tightness, and shortness of breath. You might also have a cough that won’t go away, find it hard to talk, or notice your lips or nails turning blue. These signs aren’t the same for everyone and can be set off by allergens, illness, or even just being active.
Wheezing is the key sign, a whistling sound as you breathe, often with a tight chest. Not getting enough air leads to feeling you can’t breathe deeply. A cough that sticks around, either with or without mucus, also points to asthma.
Asthma can interfere with your speech, making it hard to talk normally. This happens if you’re out of breath and have to take quick, small breaths. And in some cases, the lack of oxygen makes your lips or nails turn blue.
Remember, asthma symptoms can be mild or severe, and they’re not the same for everyone. Some might only feel sick at certain times or with certain triggers. Others may always feel unwell. Getting help from a doctor is key to keeping asthma under control.
| Symptoms of Asthma | Common Triggers |
|---|---|
| Wheezing | Allergens, physical activity |
| Chest tightness or pressure | Respiratory infections, stress |
| Shortness of breath | Allergens, exercise, cold air |
| Persistent coughing | Exposure to irritants, respiratory infections |
| Difficulty talking | Increased breathlessness, exertion |
| Blue lips or nails | Severe asthma attack, lack of oxygen |
Causes of Asthma
The causes of asthma are not fully known. Research shows it’s linked to both genes and the environment. This means people might inherit a tendency to get asthma. But, it also depends on what’s in the air we breathe.
Genetic Predisposition
If asthma runs in your family, you might get it too. This shows how important family history is. Some gene types can make our bodies react more to things in our air. This affects how our immune system and lungs work.
Environmental Factors
People say, “It takes two to tango,” and that’s true for asthma. Just being exposed to colds and flu early in life is a risk factor. Allergies, like reactions to dust or pet hair, are also big asthma triggers.
Pollution and smoking are bad for everyone’s lungs. But they’re especially risky for those with asthma. Yet, a lesser-known condition, sinusitis, can also link to asthma. This is because it can add more strain to our respiratory system.
Asthma doesn’t pick a specific age to show up. Yet, some things make it more likely for certain people. For example, if you’ve had bronchitis often or if you have a weaker immune system, you might find yourself at higher risk.
Smoking is a big no-no for asthma. It not only raises your chances of getting asthma but also makes it worse if you already have it. The bottom line is, knowing about asthma’s causes can help us prevent and manage it better. This includes working on both our genes and what’s around us.
| Causes | Examples |
|---|---|
| Genetic predisposition | Family history of asthma |
| Environmental factors | Respiratory infections, allergies, pollution, cigarette smoke, sinusitis |
| Risk factors | Frequent bronchitis, reduced immunity, smoking |
Diagnosis of Asthma
Doctors use many tests to diagnose asthma. These tests check how bad someone’s asthma is. They are key for making the right treatment plan.
Spirometry
Spirometry is a key test for asthma. It checks how well your lungs work and if your airways are blocked. You blow into a spirometer device after a deep breath.
This shows your lung health, helping with asthma diagnosis.
Exhaled Nitric Oxide Measurement
Measuring exhaled nitric oxide is another test for asthma. Nitric oxide shows if your airways are inflamed. You breathe into a special device for this test.
High nitric oxide levels suggest asthma or its severity.
Challenge Tests
Challenge tests are done if diagnosis is unclear. They test how you react to asthma triggers. Methacholine or mannitol inhalations are common for this.
These tests confirm asthma and check your asthma triggers.
Allergy Tests
Doctors might suggest allergy tests too. These find the allergens that make asthma worse. They can be skin pricks or blood tests.
In conclusion, diagnosing asthma is a thorough process. It includes spirometry, measuring nitric oxide, challenge tests, and allergy checks. All these tests help doctors find the right treatment approach for each asthma patient.
Types of Asthma
Asthma comes in various forms, each with its own causes and symptoms. Pinpointing the type is key. It helps in crafting the best treatment for a person, enhancing their health.
Allergic Asthma
Most asthmatics are allergic asthmatics. Triggers like pollen or pet dander set off their immune system. This causes airway swelling and leads to asthma signs.
Bronchial Asthma
Bronchial asthma mainly impacts the lung’s air tubes. These tubes get inflamed and narrow, making breathing tough. Various asthma effects result from this condition.
Nocturnal Asthma
Nocturnal asthma happens mostly at night. It makes people cough, wheeze, and feel breathless while they sleep. This can disturb their sleep and daily life.
Occupational Asthma
Workplace conditions can cause occupational asthma. Exposure at work to chemicals, dust, or fumes can bring it on.
Exercise-Induced Asthma
For some, working out triggers asthma symptoms. After physical activity, their airways narrow, causing coughing and chest tightness. Known as exercise-induced bronchoconstriction, it makes breathing harder.
Steroid-Resistant Asthma
Some asthma types don’t get better with usual medication. Steroid-resistant asthmatics find standard treatments ineffective. They need different approaches to handle their symptoms.
Knowing which asthma type a person has guides doctors in creating a precise care plan. This approach helps manage symptoms, elevating the patient’s life quality.
| Type of Asthma | Trigger | Symptoms |
|---|---|---|
| Allergic Asthma | Allergens (pollen, pet dander, etc.) | Coughing, wheezing, shortness of breath |
| Bronchial Asthma | Affects the bronchial tubes | Inflammation, breathing difficulties |
| Nocturnal Asthma | Symptoms predominantly at night | Coughing, wheezing, shortness of breath during sleep |
| Occupational Asthma | Workplace substances or conditions | Exposure-related symptoms |
| Exercise-Induced Asthma | Physical activity or exercise | Coughing, chest tightness, wheezing during exercise |
| Steroid-Resistant Asthma | Poor response to corticosteroid medications | Uncontrolled asthma symptoms despite treatment |
Treatment Options for Asthma
Treating asthma is all about keeping symptoms under control. It also focuses on easing inflammation and boosting lung health. The best treatments combine medicine, changes in how you live, and strategies to manage your condition.
Medications
Medicines are key for handling asthma and its symptoms. Here’s what you might use:
- Bronchodilators: These help by relaxing the airway muscles. This makes breathing easier fast. You can take them with an inhaler or a nebulizer.
- Corticosteroids: They’re anti-inflammatory. By cutting down swelling and mucus in the airways, they lessen breathing trouble. You can get them as an inhaler, a pill, or a liquid.
- Anti-inflammatory drugs: These help stop airway swelling and inflammation. They keep asthma episodes from being so often or serious. Most are taken daily to stay in control and avoid flare-ups.
Lifestyle Modifications
Along with medicine, making certain changes in your day-to-day life can work wonders. It lowers the chances of your asthma acting up. Try these:
- Finding and dodging your specific triggers. That means steering clear of things like pollen, dust mites, pet dander, smoke, very strong smells, and chemicals. Also, try to avoid people with respiratory infections.
- Staying at a healthy weight. Not being overweight helps keep symptoms from getting worse. Do this by eating right and staying active.
- Keeping up with regular exercise. It does your lungs good and keeps the rest of your breathing in top form. Make sure the activity you pick isn’t a trigger and always take your meds before you work out.
- Stopping smoking. It makes asthma worse and doesn’t help anything. Quitting will make your lungs work better and keep you healthier overall.
Stem Cell Therapy for Asthma
For some people, stem cell therapy offers a bright new path. It works by aiming to heal lung tissue and reduce inflammation. This special treatment uses the patient’s own stem cells, usually from the bone marrow or fat tissue. By tweaking the immune system and healing the lungs, it has helped some folks breathe better, have fewer symptoms, and less-frequent asthma attacks. But here’s the thing: we need more study to really see what it can do and how to make it work even better.
Treatment Options for Asthma – Summary Table
| Treatment Option | Description |
|---|---|
| Medications | Includes bronchodilators, corticosteroids, and anti-inflammatory drugs to control asthma symptoms and reduce inflammation in the airways. |
| Lifestyle Modifications | Involves avoiding triggers, maintaining a healthy weight, exercising regularly, and quitting smoking to manage asthma and reduce the risk of symptoms. |
| Stem Cell Therapy | Uses mesenchymal stem cells to promote lung tissue regeneration and reduce inflammation in the airways, providing a potential innovative approach for asthma treatment. |
Importance of Asthma Management
It’s vital to manage asthma well to control symptoms and avoid attacks. Working with health experts helps create a plan just for you.
Symptom Control
Controlling asthma means managing symptoms like coughing and chest tightness. The right medications let you keep symptoms in check and your lungs working well.
Preventing Asthma Attacks
To stop asthma attacks, find what triggers them and steer clear. This means less allergens and germs in your life. Doing this can cut down on how often and how bad attacks are.
Reducing the Risk of Complications
Ignoring asthma can lead to serious lung problems. Managing it well lowers these risks. It’s key to keeping your breathing health in good shape.
Collaboration with Healthcare Professionals
Teamwork with health pros is crucial in asthma care. They guide your meds, teach you how to use your inhaler, and check how your asthma’s doing. This helps adjust your plan as needed.
Self-Management Techniques
Knowing how to care for yourself is also important. By using tools like peak flow meters and noticing signs of trouble early, you can stay on top of your asthma. Following your prescribed meds closely is a big part of this.
Managing asthma well involves many approaches. With the right medical care, self-care, and a good doctor-patient team, asthma’s impact can be lessened. This effort can lead to a better life, less condition interference, and lower risk of serious issues.
Stem Cell Therapy for Asthma
Stem cell therapy is a new way to treat asthma. It uses special cells from a person’s own body. These cells can change the way the immune system reacts, help the lungs heal, and lessen swelling in the airways.
These special cells can turn into different cell types. They can also calm the immune response. This helps reduce allergic reactions and lung inflammation in asthma.
Studies show stem cell therapy can make breathing easier for asthma patients. It can lower asthma symptoms and reduce how often asthma attacks happen. But, more research is needed to understand the therapy’s full potential for asthma treatment.
Potential Benefits of Stem Cell Therapy for Asthma
Stem cell therapy could be important in asthma treatment by:
- Modulating the immune system to lower allergic reactions and airway inflammation
- Helping injured lung tissue heal, which improves how well a person breathes
- Improving lung function and overall respiratory health
- Decreasing how often asthma symptoms show up and how severe they are
- Making current asthma treatments work better
Even though it’s still early in research, stem cell therapy’s future looks bright. It might change how we deal with asthma. Ongoing studies aim to reveal the therapy’s true benefits, offering hope for a better life for those with asthma.
| Advantages of Stem Cell Therapy for Asthma | Challenges and Considerations |
|---|---|
|
|
Conclusion
Asthma is a health problem that affects many people around the world. Even though asthma can’t be cured, it can be managed. This entails taking the right medicine, changing your lifestyle, and knowing how to take care of yourself.
There’s exciting research happening in treating asthma with stem cells. Studies show that certain stem cells can help make breathing better, lessen swelling, and help your lungs heal. Stem cell treatments might change how we fight asthma in the years to come, making treatments more personal and effective.
Looking forward, there’s a lot of hope in new asthma treatments, including stem cell therapy. Scientists are on the path to make big changes in how we manage asthma. By keeping up with new developments, healthcare professionals aim to bring better lives to people with asthma, marked by improving health and brighter futures.
References
1. Global Initiative for Asthma. Global strategy for asthma management and prevention GINA, (2015).
2. Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N. Engl. J. Med. 1998;339:1194–1200. doi: 10.1056/NEJM199810223391703. [PubMed] [CrossRef] [Google Scholar]
3. Porsbjerg C, Lange P, Ulrik CS. Lung function impairment increases with age of diagnosis in adult onset asthma. Respir. Med. 2015;109:821–827. doi: 10.1016/j.rmed.2015.04.012. [PubMed] [CrossRef] [Google Scholar]
4. Custovic A. To what extent is allergen exposure a risk factor for the development of allergic disease? Clin. Exp. Allergy. 2015;45:54–62. doi: 10.1111/cea.12450. [PubMed] [CrossRef] [Google Scholar]
5. Amelink M. Severe adult-onset asthma: a distinct phenotype. J. Allergy Clin. Immunol. 2013;132:336–341. doi: 10.1016/j.jaci.2013.04.052. [PubMed] [CrossRef] [Google Scholar]
6. Ledford DK, Lockey RF. Asthma and comorbidities. Curr. Opin. Allergy Clin. Immunol. 2013;13:78–86. doi: 10.1097/ACI.0b013e32835c16b6. [PubMed] [CrossRef] [Google Scholar]
7. Custovic A. EAACI position statement on asthma exacerbations and severe asthma. Allergy. 2013;68:1520–1531. doi: 10.1111/all.12275. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
8. Fu L. Natural progression of childhood asthma symptoms and strong influence of sex and puberty. Ann. Am. Thorac. Soc. 2014;11:939–944. doi: 10.1513/AnnalsATS.201402-084OC. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
9. Soyka MB, van de Veen W, Holzmann D, Akdis M, Akdis CA. Scientific foundations of allergen-specific immunotherapy for allergic disease. Chest. 2014;146:1347–1357. doi: 10.1378/chest.14-0049. [PubMed] [CrossRef] [Google Scholar]
10. Murray CS, Woodcock A, Langley SJ, Morris J, Custovic A. Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomized, controlled study. Lancet. 2006;368:754–762. doi: 10.1016/S0140-6736(06)69285-4. [PubMed] [CrossRef] [Google Scholar]
11. Murray CS. Can inhaled corticosteroids influence the natural history of asthma? Curr. Opin. Allergy Clin. Immunol. 2008;8:77–81. doi: 10.1097/ACI.0b013e3282f41769. [PubMed] [CrossRef] [Google Scholar]
12. Moore WC. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am. J. Respir. Crit. Care Med. 2010;181:315–323. doi: 10.1164/rccm.200906-0896OC. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
13. World Health Organization. Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach. WHO, (2007).
14. Wang D. Cross-sectional epidemiological survey of asthma in Jinan, China. Respirology. 2013;18:313–322. doi: 10.1111/resp.12005. [PubMed] [CrossRef] [Google Scholar]
15. Jackson DJ, Hartert TV, Martinez FD, Weiss ST, Fahy JV. Asthma: NHLBI workshop on the primary prevention of chronic lung diseases. Ann. Am. Thorac. Soc. 2014;11:S139–S145. doi: 10.1513/AnnalsATS.201312-448LD. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
16. Yunginger JW. A community-based study of the epidemiology of asthma. Incidence rates. Am. Rev. Respir. Dis. 1992;146:888–894. doi: 10.1164/ajrccm/146.4.888. [PubMed] [CrossRef] [Google Scholar]
17. Butland BK, Strachan DP. Asthma onset and relapse in adult life: the British 1958 birth cohort study. Ann. Allergy Asthma Immunol. 2007;98:337–343. doi: 10.1016/S1081-1206(10)60879-4. [PubMed] [CrossRef] [Google Scholar]
18. Arshad SH. Pathophysiological characterization of asthma transitions across adolescence. Respir. Res. 2014;15:153. doi: 10.1186/s12931-014-0153-7. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
19. Szefler SJ. Advances in pediatric asthma in 2014: moving toward a population health perspective. J. Allergy Clin. Immunol. 2015;135:644–652. doi: 10.1016/j.jaci.2014.12.1921. [PubMed] [CrossRef] [Google Scholar]
20. Dumas O. Occupational irritants and asthma: an Estonian cross-sectional study of 34,000 adults. Eur. Respir. J. 2014;44:647–656. doi: 10.1183/09031936.00172213. [PubMed] [CrossRef] [Google Scholar]
21. Simpson A. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am. J. Respir. Crit. Care Med. 2010;181:1200–1206. doi: 10.1164/rccm.200907-1101OC. [PubMed] [CrossRef] [Google Scholar]
22. Tai A. Outcomes of childhood asthma to the age of 50 years. J. Allergy Clin. Immunol. 2014;133:1572–1578.e3. doi: 10.1016/j.jaci.2013.12.1033. [PubMed] [CrossRef] [Google Scholar]
23. Wu W. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J. Allergy Clin. Immunol. 2014;133:1280–1288. doi: 10.1016/j.jaci.2013.11.042. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
24. Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood— a prospective study. N. Engl. J. Med. 1990;323:502–507. doi: 10.1056/NEJM199008233230802. [PubMed] [CrossRef] [Google Scholar]
25. Permaul P. Allergens in urban schools and homes of children with asthma. Pediatr. Allergy Immunol. 2012;23:543–549. doi: 10.1111/j.1399-3038.2012.01327.x. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
26. Olivieri M. Risk factors for new-onset cat sensitization among adults: a population-based international cohort study. J. Allergy Clin. Immunol. 2012;129:420–425. doi: 10.1016/j.jaci.2011.10.044. [PubMed] [CrossRef] [Google Scholar]
27. Djukanovic R. Mucosal inflammation in asthma. Am. Rev. Respir. Dis. 1990;142:434–457. doi: 10.1164/ajrccm/142.2.434. [PubMed] [CrossRef] [Google Scholar]
28. Fajt ML, Wenzel SE. Mast cells, their subtypes, and relation to asthma phenotypes. Ann. Am. Thorac. Soc. 2013;10:S158–S164. doi: 10.1513/AnnalsATS.201303-064AW. [PubMed] [CrossRef] [Google Scholar]
29. Brightling CE. Mast-cell infiltration of airway smooth muscle in asthma. N. Engl. J. Med. 2002;346:1699–1705. doi: 10.1056/NEJMoa012705. [PubMed] [CrossRef] [Google Scholar]
30. Balzar S. Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. Am. J. Respir. Crit. Care Med. 2011;183:299–309. doi: 10.1164/rccm.201002-0295OC. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
31. Holgate ST. Innate and adaptive immune responses in asthma. Nat. Med. 2012;18:673–683. doi: 10.1038/nm.2731. [PubMed] [CrossRef] [Google Scholar]
32. Fahy JV. Type 2 inflammation in asthma — present in most, absent in many. Nat. Rev. Immunol. 2015;15:57–65. doi: 10.1038/nri3786. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
33. Truyen E. Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax. 2006;61:202–208. doi: 10.1136/thx.2005.052399. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
34. Chesné J. IL-17 in severe asthma. Where do we stand? Am. J. Respir. Crit. Care Med. 2014;190:1094–1101. doi: 10.1164/rccm.201405-0859PP. [PubMed] [CrossRef] [Google Scholar]
35. Neill DR. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010;464:1367–1370. doi: 10.1038/nature08900. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
36. Kim HY, DeKruyff RH, Umetsu DT. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat. Immunol. 2010;11:577–584. doi: 10.1038/ni.1892. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
37. Martinez-Gonzalez I, Steer CA, Takei F. Lung ILC2s link innate and adaptive responses in allergic inflammation. Trends Immunol. 2015;36:189–195. doi: 10.1016/j.it.2015.01.005. [PubMed] [CrossRef] [Google Scholar]
38. Jain VV, Perkins DL, Finn PW. Costimulation and allergic responses: immune and bioinformatic analyses. Pharmacol. Ther. 2008;117:385–392. doi: 10.1016/j.pharmthera.2007.12.002. [PubMed] [CrossRef] [Google Scholar]
39. Lambrecht BN, Hammad H. The immunology of asthma. Nat. Immunol. 2014;16:45–56. doi: 10.1038/ni.3049. [PubMed] [CrossRef] [Google Scholar]
40. Kay AB. The role of T lymphocytes in asthma. Chem. Immunol. Allergy. 2006;91:59–75. doi: 10.1159/000090230. [PubMed] [CrossRef] [Google Scholar]
41. Jacquet A. Interactions of airway epithelium with protease allergens in the allergic response. Clin. Exp. Allergy. 2011;41:305–311. doi: 10.1111/j.1365-2222.2010.03661.x. [PubMed] [CrossRef] [Google Scholar]
42. Lambrecht BN, Hammad H. Biology of lung dendritic cells at the origin of asthma. Immunity. 2009;31:412–424. doi: 10.1016/j.immuni.2009.08.008. [PubMed] [CrossRef] [Google Scholar]
43. Kemeny DM. The role of the T follicular helper cells in allergic disease. Cell. Mol. Immunol. 2012;9:386–389. doi: 10.1038/cmi.2012.31. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
44. Perros F, Hoogsteden HC, Coyle AJ, Lambrecht BN, Hammad H. Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation. Allergy. 2009;64:995–1002. doi: 10.1111/all.12275. [PubMed] [CrossRef] [Google Scholar]
45. Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J. Allergy Clin. Immunol. 2006;117:1277–1284. doi: 10.1016/j.jaci.2006.02.039. [PubMed] [CrossRef] [Google Scholar]
46. Ma LL, O’Byrne PM. The pharmacological modulation of allergen-induced asthma. Inflammopharmacology. 2013;21:113–124. doi: 10.1007/s10787-012-0155-3. [PubMed] [CrossRef] [Google Scholar]
47. Hargreave FE, Dolovich J, O’Byrne PM, Ramsdale EH, Daniel EE. The origin of airway hyperresponsiveness. J. Allergy Clin. Immunol. 1986;78:825–832. doi: 10.1016/0091-6749(86)90226-5. [PubMed] [CrossRef] [Google Scholar]
48. Diamant Z. Inhaled allergen bronchoprovocation tests. J. Allergy Clin. Immunol. 2013;132:1045–1055.e6. doi: 10.1016/j.jaci.2013.08.023. [PubMed] [CrossRef] [Google Scholar]
FAQ
Q: What is asthma?
A: Asthma is a lung disease that causes airway inflammation. This can lead to wheezing, coughing, and feeling like you can’t catch your breath. It’s a condition you’ll have for a long time.
Q: What are the symptoms of asthma?
A: When you have asthma, you might wheeze when you breathe. You could feel pressure in your chest or find it hard to talk. Your fingers or lips might turn blue, and coughing can be constant.
Q: What causes asthma?
A: Doctors aren’t sure about the exact causes of asthma. But they think both your genes and what’s in the environment around you can play a big part. Things like a family history of asthma, infections, allergies, pollution, smoking, and sinus issues might make asthma more likely.
Q: How is asthma diagnosed?
A: Doctors use special tests to figure out if you have asthma. These include measuring how well your lungs work, checking for inflammation in your airways, and seeing if certain things make your asthma worse. This helps them make a clear diagnosis.
Q: What are the different types of asthma?
A: There are many types of asthma. Some of the common ones include allergic asthma, which is set off by allergens, and exercise-induced asthma, which shows up when you play sports. Other kinds include asthma that flares up at night, asthma from work conditions, and a type that doesn’t get better with steroid drugs.
Q: What are the treatment options for asthma?
A: Asthma treatment helps to keep symptoms under control and your airways less inflamed. Doctors might give you medicines to use with an inhaler, like bronchodilators. There are also pills and lifestyle changes to help. In some cases, stem cell therapy could be a new way to treat asthma.
Q: How important is asthma management?
A: Managing asthma well is key for staying healthy. By working with your doctors, taking medicine as they suggest, and avoiding what sets off your asthma, you can keep it from causing bigger problems. It’s all about staying on top of your health with a solid plan.
Q: What is stem cell therapy for asthma?
A: Stem cell therapy is a new way to help with asthma. It uses special cells to help your body calm down its overactive defense, repair your lungs, and decrease the swelling. This method seems to be good at making your breathing and overall asthma symptoms better.
Q: What are the benefits of stem cell therapy for asthma?
A: With stem cell therapy, your immune system might get stronger, your lungs might heal, and you could see less trouble from your asthma. It has been positive in studies, improving how well your lungs work, cutting back your symptoms, and reducing how often severe attacks happen.
Q: Is there a cure for asthma?
A: Right now, asthma can’t be cured, but it can be well-managed. This is done with medicines, healthy habits, and keeping an eye on your own health. As a new possibility, stem cell therapy could offer hope for better asthma care in the future.